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PacBio was founded in 2004 to develop sequencing methods based on work done in the labs of biophysicist Watt Webb and engineer Harold Craighead, both at Cornell University. The previous year, the two had collaborated to create zero-mode waveguides (ZMWs): small containers just big enough to hold a single DNA polymerase and containing tiny holes at the bottom through which light could be detected. They were able to fix a DNA polymerase to the bottom of a ZMW and detect the incorporation of individual fluorescent “C” nucleotides through the holes, which fed into a microscope capable of detecting light emissions.

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廖祥忠认为,推动高等教育模式创新,关键在课堂教学改革。要以课堂效果为导向,将思政教育、通识教育、专业教育有机整合,推动教师角色转型,突出“师—生—机”三元协同,提升教学效果。